Bilateral Ovarian Metastases from ALK Rearranged Non-Small Cell Lung Cancer.
10.4046/trd.2014.77.6.258
- Author:
Kyung Ann LEE
1
;
Jong Sik LEE
;
Jae Ki MIN
;
Hee Joung KIM
;
Wan Seop KIM
;
Kye Young LEE
Author Information
1. Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea. kyleemd@kuh.ac.kr
- Publication Type:Case Report
- Keywords:
Anaplastic Lymphoma Kinase;
Carcinoma, Non-Small-Cell Lung;
Neoplasm Metastasis;
Ovary
- MeSH:
Adenocarcinoma;
Carcinoma, Non-Small-Cell Lung*;
Drug Therapy;
Female;
Humans;
Lung;
Lung Neoplasms;
Lymphoma;
Middle Aged;
Neoplasm Metastasis*;
Ovary;
Phosphotransferases
- From:Tuberculosis and Respiratory Diseases
2014;77(6):258-261
- CountryRepublic of Korea
- Language:English
-
Abstract:
Anaplastic lymphoma kinase (ALK) rearrangement, is a kind of driver mutation, accounts for 3%-5% of non-small cell lung cancer (NSCLC). NSCLC patients harboring ALK fusion genes have distinct clinical features and good response to ALK inhibitors. Metastasis from lung cancer to the ovary has rarely been known. We report a case of a 54-year-old woman with bilateral ovarian metastases from ALK rearranged NSCLC. She underwent bilateral salpingo-oophorectomy for ovary masses, which were progressed after cytotoxic chemotherapy although primary lung mass was decreased. Histopathological examination of the ovary tumor showed characteristic adenocarcinoma patterns of the lung and ALK rearrangement.
