A Case of Organizing Pneumonia Associated with FOLFIRI Chemotherapy.
10.4046/trd.2014.77.6.262
- Author:
Yoon Jeong LEE
1
;
Jun Hyun KIM
;
Sun Woong KIM
;
Won Chan KANG
;
Soo Jung KIM
;
Ji Hye KIM
;
Sun Jong KIM
Author Information
1. Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine, Seoul, Korea. sjkim@kuh.ac.kr
- Publication Type:Case Report
- Keywords:
Irinotecan;
IFL Protocol;
Cryptogenic Organizing Pneumonia;
Colorectal Neoplasmsoxaliplatin
- MeSH:
Biopsy;
Bronchiolitis Obliterans;
Colorectal Neoplasms;
Cough;
Cryptogenic Organizing Pneumonia;
Drug Therapy*;
Drug Therapy, Combination;
Dyspnea;
Fluorouracil;
Humans;
Leucovorin;
Lung;
Middle Aged;
Pneumonia*
- From:Tuberculosis and Respiratory Diseases
2014;77(6):262-265
- CountryRepublic of Korea
- Language:English
-
Abstract:
The combination chemotherapy of irinotecan with 5-fluorouracil and leucovorin (FOLFIRI regimen) was recently proven to be beneficial in patients with advanced colorectal cancer. Pulmonary toxicity is very rare in adverse effects of irinotecan. No case of organizing pneumonia (also known as bronchiolitis obliterans organizing pneumonia) associated with FOLFIRI chemotherapy has been reported. We experienced a case of a 62-year-old man who presented persistent dry cough and progressive dyspnea after receiving chemotherapy with FOLFIRI regimen. After surgical lung biopsy, the patient was diagnosed with FOLFIRI chemotherapy-induced organizing pneumonia which was successfully treated with steroid therapy.
