Genetic polymorphisms of CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 in Vietnamese-Koreans.
10.12793/tcp.2014.22.2.70
- Author:
Ye Ji LIM
1
;
Eun Young CHA
;
Hye Eun JUNG
;
Jong Lyul GHIM
;
Su Jun LEE
;
Eun Young KIM
;
Jae Gook SHIN
Author Information
1. Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 614-735, Republic of Korea. phshinjg@gmail.com
- Publication Type:Comparative Study ; Original Article
- Keywords:
Racially mixed Korean;
Cytochrome P450;
Genetic polymorphism;
Vietnamese;
Korean
- MeSH:
Alleles;
Asian Continental Ancestry Group;
Censuses;
Cytochrome P-450 CYP2D6*;
Cytochrome P-450 Enzyme System;
DNA;
Fathers;
Genotype;
Humans;
Mothers;
Polymorphism, Genetic*
- From:Translational and Clinical Pharmacology
2014;22(2):70-77
- CountryRepublic of Korea
- Language:English
-
Abstract:
The Vietnamese-Koreans, especially offspring between a Vietnamese mother and a Korean father constituted the highest proportion (64.2%) of total Kosian population according to a census in 2014. To evaluate genetic characteristics in the Vietnamese-Koreans, a total of 25 alleles from CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 were genotyped using SNaPshot method with DNA samples of 127 Vietnamese-Koreans. The previous reports on the CYPs of Korean and Vietnamese populations were also analyzed for the comparative studies for the frequencies of CYP alleles. The statistical significances in allele and genotype frequencies among the ethnics were analyzed by Chi-square or Fisher's exact probability test. Although most of variants analyzed in 5 CYPs did not reach the statistically significant difference between the Vietnamese-Koreans and Vietnamese, some alleles were only found in Vietnamese-Koreans. Compared with Korean population, frequencies of CYP2D6*1 and CYP2D6*10B were statistically different from Vietnamese-Koreans (p<0.05). This is the first report to describe the CYP genotype profiles of Vietnamese-Koreans, which may provide important insight for the genotype based prediction of CYP activities of this admixture of Korean and Vietnamese.
