The effect of remifentanil infusion on coughing during emergence from general anesthesia with desflurane.
10.4097/kjae.2008.55.6.670
- Author:
Hyeok Rae CHO
1
;
Hae Kyu KIM
;
Seung Hoon BAEK
;
Kyu Youn JUNG
Author Information
1. Department of Anesthesia and Pain Medicine, Pusan National University School of Medicine, Busan, Kroea. hakykim@pusan.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
cough;
desflurane;
emergence;
remifentanil
- MeSH:
Anesthesia, General;
Cough;
Humans;
Incidence;
Isoflurane;
Piperidines;
Receptors, Peptide;
Surgery, Oral
- From:Korean Journal of Anesthesiology
2008;55(6):670-674
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Coughing during emergence from general anesthesia is a common clinical problem and results in a number of undesirable side effects. Remifentanil stimulate micron-opioid peptide receptor known to be related to antitussive effect. The goal of this study was to evaluate the effect of remifentanil on coughing after general anesthesia with desflurane. METHODS: Fifty one ASA physical status I and II patients undergoing elective oral and maxillofacial surgery were randomly assigned to receive either remifentanil with 1 ng/ml effect site concentration or normal saline until extubation. The number and intensity of coughs were monitored during emergence and the recovery time was recorded. RESULTS: The incidence and number of coughing during emergence was significant less frequent in the remifentanil group (P < 0.05). The intensity of coughing was significant milder in the remifentanil group (P < 0.05). There was no significant difference between two groups in the recovery time. CONCLUSIONS: Continuous remifentanil infusion with 1 ng/ml effect site concentration during emergence from general anesthesia with desflurane decrease the incidence of coughing without delaying the recovery time.
