The effect of remifentanil on sedation during midazolam induced sedation under brachial plexus block.
10.4097/kjae.2008.55.6.680
- Author:
Sung Jun HONG
1
;
Ji Soo KIM
;
Sung Mi HWANG
;
Jae Jun LEE
;
So Young LIM
Author Information
1. Department of Anesthesiology and Pain Medicine, Hallym University College of Medicine, Chuncheon, Korea. h70sm@hallym.or.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
bispectral index (BIS);
midazolam;
remifentanil;
sedation
- MeSH:
Adult;
Arterial Pressure;
Brachial Plexus;
Heart Rate;
Humans;
Midazolam;
Piperidines;
Respiratory Rate;
Upper Extremity
- From:Korean Journal of Anesthesiology
2008;55(6):680-684
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The effects of remifentanl on bispectral index (BIS) and sedation are controversial. The aim of this study was to evaluate the effects of continuous remifentanil infusion (0.03microgram/min/kg) on sedation by using BIS and the modified Observer's Assessment of the Alertness/Sedation Scale (OAA/S) during midazolam induced sedation after achieving pain free state by brachial plexus block. METHODS: In this study 40 ASA physical status 1 or 2 adult patients scheduled to undergo upper extremity surgery under brachial plexus anaesthesia were included. After obtaining adequate brachial plexus block, patients were randomly allocated to two groups. All patents received a single dose of midazolam 2 mg intravenously and continuous infusion (2 mg/h). At 15 minutes after midazolam injection, Group C received saline infusion and Group R received additional remifentanil (0.4microgram/kg bolus plus continuous infusion (0.03microgram/kg/min)). The mean arterial blood pressure (MAP), heart rate (HR), SpO2, respiration rate (RR), and BIS were recorded every 5 min after injection of midazolam. The patient's level of sedation was assessed using the modified OAA/S and BIS immediately after MAP, HR, SpO2, and RR measurements. RESULTS: There are no significant differences in MAP, HR, BIS, and the modified OAA/S between two groups but RR was significant reduced in Group R compared with Group C after remifentanil infusion. CONCLUSIONS: The remifentanil showed no effect on BIS and the modified OAA/S during midazolam induced sedation under pain free state.
