Prevalence and Risk Factors of Low Bone Mineral Density in Korean HIV-Infected Patients: Impact of Abacavir and Zidovudine.
10.3346/jkms.2013.28.6.827
- Author:
Hee Sung KIM
1
;
Bum Sik CHIN
;
Hyoung Shik SHIN
Author Information
1. Center for Infectious Diseases, Department of Internal Medicine, National Medical Center, Seoul, Korea. hyoungsshin@gmail.com
- Publication Type:Original Article
- Keywords:
HIV;
Acquired Immunodeficiency Syndrome;
Bone Density;
Abacavir;
Zidovudine
- MeSH:
Adult;
Anti-HIV Agents/adverse effects/*therapeutic use;
Asian Continental Ancestry Group;
Body Mass Index;
*Bone Density;
Bone Diseases, Metabolic/*epidemiology/etiology;
Dideoxynucleosides/adverse effects/*therapeutic use;
Female;
HIV Infections/*drug therapy/epidemiology/pathology;
Humans;
Male;
Middle Aged;
Odds Ratio;
Osteoporosis/*epidemiology/etiology;
Prevalence;
Republic of Korea/epidemiology;
Retrospective Studies;
Risk Factors;
Zidovudine/adverse effects/*therapeutic use
- From:Journal of Korean Medical Science
2013;28(6):827-832
- CountryRepublic of Korea
- Language:English
-
Abstract:
Low bone mineral density (BMD) is common in HIV-infected patients. We aimed to describe the prevalence of low BMD and risk factors in Korean HIV-infected patients and to assess the effects of antiretroviral therapy (ART) on BMD. We retrospectively evaluated 224 HIV infected-patients. The prevalence of osteopenia and osteoporosis were 41.5% and 12.9%. These were much higher in 53 patients aged 50 yr and older (52.8% and 34.0%). Older age, lower body mass index, and ART > 3 months were independent risk factors for low BMD. Osteoporosis was more prevalent in patients on the abacavir-based regimen for < 1 yr than > or = 1 yr; however, it was more prevalent in patients on the zidovudine-based regimen for > or = 1 yr than < 1 yr (P = 0.017). Osteoporosis in patients on the abacavir-based regimen was more common in the spine than in the femur (P = 0.01). Given such a high prevalence of low BMD, close monitoring of BMD for HIV-infected patients on ART is required. The different prevalence of osteoporosis over time and affected areas between two regimens suggest they may play roles in different mechanisms in bone loss.
