Serum Interleukin-8 Levels in Leprosy Patients.
10.5021/ad.1999.11.1.1
- Author:
Wook LEW
;
Ho KWAHCK
;
Soo Kyoung CHANG
- Publication Type:Original Article
- Keywords:
IL-8;
Leprosy
- MeSH:
Adult;
Erythema Nodosum;
Humans;
Immunoenzyme Techniques;
Interleukin-1;
Interleukin-8*;
Leprosy*;
Necrosis;
Neutrophils;
Prognosis;
RNA, Messenger;
Tuberculosis
- From:Annals of Dermatology
1999;11(1):1-4
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Interleukin(IL)-8 is a potent chemotactic factor for neutrophils which was induced by tumor necrosis factor-a and IL-1. Serum IL-8 level was known to be associated with the poor prognosis of tuberculosis and IL-8 mRNA was increased in the tissue of erythema nodosum leprosum. OBJECTIVE: Our purpose was to investigate whether the serum IL-8 levels of leprosy patients are different from those of controls and whether the severity of the leprosy is associated with the serum IL-8 level. METHODS: Twenty eight patients with leprosy and fourteen healthy adults were used in this study. Serum IL-8 levels were detected by enzyme immunoassay. RESULTS: There were no statistically significant differences in the serum IL-8 levels between the twenty eight leprosy patients and the fourteen healthy control serums (29.99±53.14 vs 2.52±7.53) nor was the detection rate between the groups (9/28 vs 1/14) significant. There were also no statistically significant differences between the serum IL-8 concentrations of the patients with high bacterial indexes and the patients with low bacterial indexes (30.22±63.64 vs 29.73±41.14). CONCLUSION: Serum levels and the detection rate of IL-8 in the leprosy patients were not different from the control group and the severity of the disease was not associated with the IL-8 levels.
