Comparison of tuberculin skin test with Interferon-gamma assay for the diagnosis of bovine tuberculosis in Korean cattle.
- Author:
Seung Won SHIN
1
;
Min Kyoung SHIN
;
Seung Bin CHA
;
Jong Tae WOO
;
Sung Mo LEE
;
Bok Kyung KU
;
Yun Sang CHO
;
Suk Chan JUNG
;
Han Sang YOO
Author Information
1. College of Veterinary Medicine and BK21 for Veterinary Science, Seoul National University, Seoul 151-742, Korea. yoohs@snu.ac.kr
- Publication Type:Original Article
- Keywords:
bovine tuberculosis;
IFN-gamma assay;
SICCT;
SIT
- MeSH:
Abattoirs;
Animals;
Cattle;
Diagnostic Tests, Routine;
Humans;
Interferon-gamma;
Interferons;
Intradermal Tests;
Mycobacterium bovis;
Skin;
Skin Tests;
Tuberculin;
Tuberculosis, Bovine
- From:Korean Journal of Veterinary Research
2011;51(2):117-121
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Bovine tuberculosis (bTB), caused primarily by Mycobacterium bovis, continues to exert an economic loss, even in countries with active control measures, and is one of zoonotic diseases enable to be transmitted to human. The control and eradication of bTB are mainly based on a test and slaughter policy and/or abattoir surveillance. Various factors including limitation of diagnostic tests have been considered as major constraints to eradication. Single intradermal test (SIT) is the official diagnostic test. New diagnostic methods are needed to be developed, because of limitations of the test. In the present study SIT was compared with single intradermal comparative cervical test (SICCT) and interferon (IFN)-gamma assay. There was very low correlation between SIT and SICCT. However, high correlation was shown between SIT and IFN-gamma assay while no correlation was observed between SICCT and IFN-gamma assay. Therefore, our results suggest the possibility of replacement of SIT with IFN-gamma assay for the diagnosis of bovine tuberculosis.
