Relationship between Metabolic Syndrome and Prostate Volume in Korean Men under 50 Years of Age.
10.4111/kju.2011.52.6.390
- Author:
Sung Jin YIM
1
;
Young Sam CHO
;
Kwan Joong JOO
Author Information
1. Department of Urology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. urojoo@dreamwiz.com
- Publication Type:Original Article
- Keywords:
Metabolic syndrome;
Prostate;
Prostatic hyperplasia;
Risk factors
- MeSH:
Aged;
Digital Rectal Examination;
Fasting;
Glucose;
Health Promotion;
Humans;
Logistic Models;
Male;
Plasma;
Prostate;
Prostate-Specific Antigen;
Prostatic Hyperplasia;
Risk Factors;
Urinalysis;
Waist Circumference;
Young Adult
- From:Korean Journal of Urology
2011;52(6):390-395
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The metabolic syndrome (MS) has been accepted as an important cause of benign prostatic hyperplasia (BPH) in old age. However, there are no studies of the influence of MS on prostate volume in relatively young adults. We evaluated the relationship between parameters of MS and prostate volume in men under 50 years of age who visited our health promotion center. MATERIALS AND METHODS: A total of 968 men aged 30 to 49 years were enrolled from March 2009 to June 2010. Prostate volume by transrectal ultrasonography of the prostate, serum prostate-specific antigen, digital rectal examination, urinalysis, and MS-related parameters were investigated. We evaluated the correlations of prostate volume with MS and MS-related parameters. RESULTS: Prostate volume was not significantly larger in the MS group (18.4 cc; range: 14.3-23.1 cc) than in the non-MS group (17.8 cc; range, 13.6-21.6 cc). The prostate volumes in subjects with abnormal fasting plasma glucose (FPG) (18.9 cc; range, 14.3-22.7 cc) and abnormal waist circumference (WC) (19.5 cc; range, 15.6-23.7 cc) were significantly larger than those of subjects with normal parameters (16.9 [range, 12.7-20.4] cc and 17.5 [range, 13.3-21.2] cc, respectively; p=0.001). The logistic regression analysis showed the FPG level and WC to have a significantly positive correlation with the prostate volume (odds ratios: 1.441 [95% CI: 1.303-1.643] and 2.305 [95% CI: 1.470-3.614], respectively). CONCLUSIONS: Groups with abnormal FPG and WC had larger prostate volumes than did normal groups. The abnormal FPG and WC could be more important factors than MS in prostate volume enlargement in relatively young adults.
