The Clinical Types and Characteristics of Diabetes Mellitus in Korean Children.
- Author:
Eun Gyong YOO
1
;
Hye Jung SHIN
;
Duk Hi KIM
Author Information
1. Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea.
- Keywords:
Diabetes mellitus;
Classification;
Type 1;
Type 2;
C-peptide
- MeSH:
Age of Onset;
Antibodies;
Autoantibodies;
C-Peptide;
Child*;
Classification;
Cytoplasm;
Diabetes Mellitus*;
Follow-Up Studies;
Humans;
Insulin;
Islets of Langerhans;
Ketosis;
Korea;
Reference Values
- From:Journal of the Korean Pediatric Society
2000;43(12):1591-1598
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Diabetic children should be classified into type 1 or 2 for adequate diabetic control. However, there is a shortage of information of the appropriate criteria in Korea. This study is desinged to discover the clinical types and characteristics of diabetes mellitus(DM) in Korean children. METHODS: We studied the clinical characteristics and laboratory findings of 177 diabetic children. Classification was based on the serum C-peptide levels, presence of ketoacidosis, autoantibodies, and insulin dependence. RESULTS: Among 177 diabetic children, 147(83.1%) were classified as type 1 and 21(11.9%) as type 2, and 12(57.1%) children in type 2 were obese. All patients with age of onset before 9 were type 1. In cases of type 1, initial serum C-peptide levels were < 0.6(50%), 0.6-1.0(44%) and > 1.0ng/mL (6%). All patients with initial serum C-peptide level above 1.5ng/mL were type 2. Four patients initially diagnosed as type 2 DM changed to type 1 during follow-up, and 2 patients of type 1 DM changed to type 2. Only 55.4% of type 1 DM patients had insulin autoantibody, islet cell cytoplasmic antibody or anti-glutamic acid decarboxylase antibodies. CONCLUSION: Most diabetic children in Korea were classified as type 1. Our results suggest that insulin requiring lean patients with positive autoantibody should be classified as type 1 even if their serum C-peptide levels are within normal range, and the clinical types could be changed during follow-up in a small proportion of diabetic children.
