Expression of p53 and MHC Class I According to HPV Infection in Laryngeal Squamous Cell Carcinomas.
- Author:
Chan Seung HWANG
1
;
Hoon KIM
;
Mi Kyung KIM
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chung-Ang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Human papillomavirus;
p53;
MHC class I;
Laryngeal carcinoma
- MeSH:
Carcinoma, Squamous Cell*;
DNA;
Down-Regulation;
In Situ Hybridization
- From:Journal of the Korean Cancer Association
1998;30(1):1-11
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We evaluated the HPV type 16, 18 infection and p53 expression and MHC class Iantigen expression, and analyzed he relationship between HPV infection and p53 expression and MHC class I expression in laryngeal squamous cell carcinomas. MATERIALS AND METHODS: Thirty-nine cases of laryngeal squamous cell carcinomas and ten cases of laryngeal nodules were analyzed for detection of HPV DNA by in situ hybridization and the detection of p53 and MHC class I antigen by immunohistochemical technique. RESULTS: HPV DNA was detected in 10(26%), and p53 expression was detected in 19(49%) out of 39 cases in laryngeal squamous cell carcinomas. HPV positive cases showed 50% of p53 expression whereas HPV negative cases showed 48% expression. MHC class I down-regulation (heterogenous and negative expression) in HPV positive lesions was higher than HPV negative lesions, but there was no statistically significance. The expression of MHC class I was related to cellular differentiation regardless of T-stage and nodal involvement. CONCLUSION: There was no reiationship between HPV infection and p53 expression and MHC class I expression in laryngeal squamous cell carcinomas. Also these results suggest that MHC class I expression can make it possible to presume indirectly the malignant potentiality of the tumor.
