bcl-2 and p53 Gene Expression in Colonic Adenoma and Carcinoma.
- Author:
Chang Young LIM
1
;
Jeong Won KIM
;
Il Han SONG
;
Young Joo JIN
;
Im Whan RHO
;
Dong Kook PARK
;
Jeong Hee CHO
;
Sung Bae CHOI
Author Information
1. Department of Internal Medicine, College of Medicine, Dankook Universirty, Cheonan, Korea.
- Publication Type:Original Article
- Keywords:
Colonic adenoma;
Colonic carcinoma;
bcl-2 gene;
p53 gene
- MeSH:
Adenoma*;
Apoptosis;
Carcinogenesis;
Colon*;
Colonic Neoplasms;
Genes, bcl-2;
Genes, p53*;
Genes, Tumor Suppressor
- From:Journal of the Korean Cancer Association
1998;30(1):89-99
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Recently, it is suggested that the inhibitian of apoptosis is associated with tumorigenesis of colon. Bcl-2 gene is an important inhibitory regulator of apoptosis, and bcl-2 acts antagonistly with the wild type p53 gene, one of the tumor suppressor genes, in apoptosis. To detnmine the role of bcl-2 and p53 gene in colonic tumorigenesis, we performed the study. MATERIALS AND METHODS: We tested the tissue obtained by polypectomy and surgical resection by immunohistochemical staining for Bcl-2 and p53. RESULTS: We found that in normal colonic tissue, the Bcl-2 was sparcely expressed, and the p53 was expressed sporadically. The rate of positivity of staining was below 5%. However, in colonic adenoma and colon cancer tissue, Bcl-2 and p53 were expressed more than in nonnal colonic tissue(p<0.05). (Scoring in Colonic adenoma: Bcl-2 6.2+/-1.1, p53 5.7+/-1.0; Scoring in Colonic carcinoma: Bcl-2 4.7+/-1.0, p53 8.3+/-0.9) CONCLUSION: Our results suggested that the bcl-2 and p53 play an important role in colonic tumorigenesis.
