A case of primary hyperparathyroidism with hypercalcemic nephropathy in children.
10.3346/jkms.1994.9.3.268
- Author:
Jae Myung YU
1
;
Heui Jung PYO
;
Dong Seop CHOI
;
Kang Woo LEE
;
Kee Hwan YOO
;
Chong Suk KIM
Author Information
1. Department of Internal Medicine, College of Medicine, Hallym University, Seoul, Korea.
- Publication Type:Case Reports
- Keywords:
Primary hyperparathyroidism;
Hypercalcemic nephropathy;
Parathyroid hyperplasia;
Children
- MeSH:
Case Report;
Child;
Human;
Hypercalcemia/*etiology;
Hyperparathyroidism/*complications/pathology;
Hyperplasia;
Kidney/pathology;
Kidney Diseases/*etiology;
Male;
Parathyroid Glands/pathology
- From:Journal of Korean Medical Science
1994;9(3):268-272
- CountryRepublic of Korea
- Language:English
-
Abstract:
Primary hyperparathyroidism is a rare disease in children and is characterized by conspicuous skeletal and renal changes. A 12 year old male patient presented with symptoms of polydipsia, polyuria, general weakness, nausea, and vomiting which had begun 3 months earlier, and showed typical laboratory findings of primary hyperparathyroidism. Confirmatory diagnosis was made by elevated parathyroid hormone concentration in serum, technetium-thallium subtraction scan imaging method and histopathologic finding of chief cell hyperplasia. The laboratory findings revealed elevated levels of BUN, creatinine and decreased GFR. Kidney biopsy showed typical calcium deposits in tubules with marked tubulointerstitial infiltration. After subtotal parathyroidectomy, clinical findings improved remarkably.
