A Case of Acute Generalized Exanthematous Pustulosis.
- Author:
Hae Jin PARK
;
Ho Jung KANG
;
Jeong Hee HAHM
- Publication Type:Case Report
- Keywords:
Acute generalized exanthematous pustulosis;
Drug eruption;
Amoxicillin
- MeSH:
Abdomen;
Acute Generalized Exanthematous Pustulosis*;
Amoxicillin;
Anti-Bacterial Agents;
Axilla;
Biopsy;
Drug Eruptions;
Edema;
Eosinophils;
Fever;
Hypersensitivity;
Keratinocytes;
Necrosis;
Purpura;
Vasculitis
- From:Korean Journal of Dermatology
1997;35(1):160-164
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acute generalized exanthematous pustulosis (AGEP) has symptoms of abrupt onset of a widespread pustular eruption on an erythematous. base. Most cases appear to be related to drug reactions, mainly antibiotics, but viral infections and hypersensitivity to mercury may cause AGEP. The essential features of AGEP include. (1) numerous (several dazen) small((5mm), mostly non follicular pustules arising on a widespread erythema:purpura and target-like lesions may be associated; (2) histology showing intraepidermal or subcorneal pustules associated with one or more of the following.clermal edema, vasculitis, perivascular eosinophils, or focal necrosis of keratinocytes; (3) fever (over 38C); (4) neutrophilia, and (5) acute evolution with spontaneous resulotion of pustules within 15 days. We report a case of AGEP which presented with widespread tiny pustules on the whole body except the face, palms and soles. There were petechia, purpura, and vesiculobullous lesions on the axilla, popliteal fossa and upper abdomen. A biopsy specimen from a pustule showed subcorneal pustules with perivascular polymorphous cellular infiltration, marked dermal edema and necrotic keratinocytes. There was complete resolution of the lesions within 10 days.
