Clinical Study of Gonorrhea: VI . Comparison of Kanamycin with Fortified Penicillin G in the Treatment of Male Gonorrhoea.
- Author:
Sung Woo HONG
;
Joong Hwan KIM
- Publication Type:Original Article
- MeSH:
Cefuroxime;
Gonorrhea*;
Humans;
Kanamycin*;
Male*;
Penicillin G*;
Penicillinase;
Penicillins*;
Probenecid;
Public Health;
Seoul;
Spectinomycin;
Treatment Failure;
Urethritis
- From:Korean Journal of Dermatology
1983;21(3):273-277
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Although penicillin still remains the drug of choice in the treatment of gonorrhoea in many countries, treatment failures are becoming more and more coramon. Recently, the prohlem cauaed, by antibiotic resistant strains of N. gnorrhoeae has been aggravated by appearance of penicillinase producing N. gonorrheeae. Good results were reported with the use of spectinomycin, cefuroxime and efotaxime. These drugs are, as yet, quite expensive. A lower cost regimen has to be sought. In this study, the effect of fortified penicillin G was compared with kanarnycin in the treatment of uncomplicated male gonorrhoeae. The subjects were 446 rnale patients with uncomplieated gonocoacal urethritis at VD clinic of ChoongKu Public Health Center in Seoul between June and November, 1981. The patients are assigned randomly to one of the regimens. Among 181 patients treated with kanamycin, 2. 0 gm, IM, 148 recovered with 27 (19%) postgonococcal urethritis (PGU) and 39(21,6%) failed. Among 168 patients treated with fortified penicillin G, 6 mega-units IM, plus probenecid, l. 0 gm, PO., 100 recovered with 31(81%) PGU and 68(40. 5%) failed. -countinue-
