Analysis of the Expression of Peroxiredoxin I in Human Bladder Cancer.
10.4111/kju.2008.49.4.300
- Author:
Eun Tak KIM
1
;
Hyuk SAGONG
;
Wun Jae KIM
Author Information
1. Department of Urology, College of Medicine, Eulji University, Daejeon, Korea.
- Publication Type:Original Article
- Keywords:
Peroxiredoxin I;
Bladder tumor
- MeSH:
Apoptosis;
Cell Differentiation;
Humans;
Mucous Membrane;
Peroxiredoxins;
RNA, Messenger;
Urinary Bladder;
Urinary Bladder Neoplasms
- From:Korean Journal of Urology
2008;49(4):300-306
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Peroxiredoxins(PRDXs) are antioxidant enzymes that play an important role on cell differentiation, proliferation and apoptosis. In this study, we investigated if the expression levels of PRDX I were related to bladder cancer. MATERIALS AND METHODS: The mRNA level of PRDX I was examined via real time polymerase chain reaction(PCR) in 186 cancer specimens from patients with primary bladder cancer, 73 corresponding samples of normal looking bladder mucosae surrounding the cancer and 21 samples of normal bladder mucosae. We investigated the correlation between the expression levels of PRDX I and the clinico-pathological parameters of the 154 patients who could be followed up more than three years. RESULTS: The expression levels of PRDX I in bladder cancer(0.73pg/ml) were significantly higher that that in the normal bladder mucosae (0.04 pg/ml)(p<0.01) or that in the corresponding normal bladder mucosae surrounding the cancer(0.38pg/ml)(p<0.01). The expression level of PRDX I was not significantly enhanced in the non-recurred(0.87pg/ml) superficial bladder tumor patients compared with the recurred superficial bladder tumor patients(0.63pg/ml), but it was significantly enhanced in the non-progressed(0.82pg/ml) patients compared with the progressed (0.50pg/ml) patients(p<0.05 for each). CONCLUSIONS: An enhanced expression of PRDX I is strongly associated with the development of bladder cancer. Moreover, enhanced expressions of PRDX I are also positively associated with a low rate of progression of bladder cancer, and this might be useful as a marker for assessing progression in human bladder cancers.
