The Effects of Vasopressin and Desmopressin on the Contractile and Relaxation Responses of Rabbit Cavernosal Smooth Muscle.
10.4111/kju.2008.49.4.366
- Author:
Hyung Oh SHIN
1
;
Soon Chul MYUNG
;
Sae Chul KIM
;
Moo Yeol LEE
Author Information
1. Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea. saeckim@unitel.co.kr
- Publication Type:Original Article
- Keywords:
Vasopressins;
Desmopressin;
Cavernosal smooth muscle;
Contraction;
Relaxation
- MeSH:
Baths;
Caves;
Contracts;
Deamino Arginine Vasopressin;
Erectile Dysfunction;
Indomethacin;
Male;
Muscle, Smooth;
Muscles;
NG-Nitroarginine Methyl Ester;
Rabbits;
Relaxation;
Vasopressins
- From:Korean Journal of Urology
2008;49(4):366-372
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study aimed to investigate the effects of vasopressin and desmopressin on the contractile and relaxative responses of rabbit cavernosal smooth muscle. MATERIALS AND METHODS: Isometric tension studies were conducted to investigate the effects of vasopressin(10(-14)-10(-8)M) and desmopressin(10(-14)- 10(-8)M) on the contraction and relaxation responses of rabbits cavernous muscle strips in an organ bath. The effects of pretreatment with phenylephrine(10(-5)M), L-NAME(10(-5)M) and indomethacin(10(-5)M) on the contraction and relaxation responses of the vasopressin and desmopressin were also investigated. The statistics were analyzed by Student's t-test and ANOVA. RESULTS: Vasopressin contracted the strips in a dose-dependent manner, while desmopressin did not. The phenylephrine-induced contraction was dose-dependently increased by vasopressin, but it was dose-dependently relaxed by desmopressin. L-NAME pre-treatment did not block the relaxation response, but indomethacin pre-treatment did. Vasopressin- induced contraction occurred the via V(1) receptor, while desmopressin- induced relaxation occurred via the V(2) receptor. CONCLUSIONS: Vasopressin, in pathophysiological circumstances, would worsen erectile dysfunction. On the contrary, desmopressin, which may induce an endothelium-dependent relaxation of the cavernous smooth muscles, would be good for erectile function.
