A Case of Esophageal Involvement of Cicatrical Pemphigoid.
- Author:
Kyoung Oh KIM
1
;
Yong Sik KIM
;
Rok Son CHOUNG
;
Young Sun KIM
;
Yun Bae KIM
;
Jae Hong PARK
;
Dong Kyu PARK
;
Yoon Tae JEEN
;
Hoon Jai CHUN
;
Soon Ho UM
;
Chang Duck KIM
;
Ho Sang RYU
;
Jin Hai HYUN
Author Information
1. Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. kumcge@cohllian.net
- Publication Type:Case Report
- Keywords:
Cicatrical pemphigoid;
Esophagus
- MeSH:
Aged;
Autoantibodies;
Basement Membrane;
Blister;
Cicatrix;
Complement System Proteins;
Deglutition Disorders;
Dyspnea;
Esophagus;
Female;
Fibrin;
Hoarseness;
Humans;
Immunoglobulin G;
Immunoglobulins;
Mucous Membrane;
Oral Ulcer;
Pemphigoid, Bullous*;
Skin;
Ulcer
- From:Korean Journal of Gastrointestinal Endoscopy
2001;23(6):461-465
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cicatrical pemphigoid is regarded as a chronic, autoimmune subepithelial blistering disease of mucous membranes in which lesions often heal with scar formation. Cicatrical pemphigoid typically involves the oral and/or ocular mucosa but may affect the nasal, pharyngeal, laryngeal, esophageal, anogenital regions as well. Immunopathologic studies have shown that patients with cicatrical pemphigoid typically have autoantibodies directed against basement membrane antigens and that they demonstrate continuous deposits of immunoglobulins (IgG, A), complement components and fibrin along the basement membrane. A 69-year-old female was admitted with chief complaints of hoarseness, dyspnea, multiple painful oral ulcer and vesiculobullous skin lesion on upper trunk. During admission, dysphagia and epigastric discomfort was developed. Endoscopic examination revealed multiple erosion and ulcerative lesion with scar formation. Immunopathologic studies showed that linear deposit of IgG, A, C3 along the basement membrane zone. We report a case of cicatrical pemphigoid with esophageal involvement with brief review of literature.
