A Case of IgA Nephropathy Associated with Non-Hodgkin's Lymphoma.
- Author:
Yon Soo JEONG
;
Hyoung Joon LEE
;
Jin Soo KIM
;
Eun Young LEE
;
Seung Ok CHOI
;
Chong In LEE
;
Young Hak SHIM
;
Soon Won HONG
- Publication Type:Case Report
- Keywords:
IgA nephropathy;
Non-Hodgkin's Lymphoma;
Paraneoplastic syndrome
- MeSH:
Biopsy;
Cyclophosphamide;
Doxorubicin;
Drug Therapy;
Drug Therapy, Combination;
Erythrocytes;
Female;
Fever;
Fever of Unknown Origin;
Gangwon-do;
Glomerulonephritis;
Glomerulonephritis, IGA*;
Hematuria;
Hodgkin Disease;
Humans;
Immunoglobulin A*;
Lymphocytes, Null;
Lymphoma;
Lymphoma, Non-Hodgkin*;
Middle Aged;
Neck;
Nephrosis, Lipoid;
Paraneoplastic Syndromes;
Prednisone;
Proteinuria;
Urinalysis;
Vincristine
- From:Korean Journal of Nephrology
1998;17(5):813-817
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The development of glomerular injury in patients with malignancy is considered as paraneoplastic syndrome. The most frequently observed renal lesions associated with malignancies are the membraneous glomerulonephritis on carcinomas and minimal change nephrotic syndrome on Hodgkin's disease. However, glomerular diseases on non-Hodgkin's lymphoma were only occasionally reported. Here we report a case of IgA nephropathy associated with non-Hodgkin's lymphoma. A 53-year-old woman who had complained of gross hematuria and fever was admitted to Wonju Christian Hospital. A urinalysis revealed 2+ proteinuria and red blood cells >30/HPF. A 24-hour urinary protein excretion was 379mg. She was diagnosed as IgA nephropathy on renal biopsy. Subsequently, biopsy of her enlarged neck node was performed for evaluation of fever of unknown origin and it revealed non-Hodgkin's lymphoma (Ki-1 positive anaplastic lymphoma null cell type). Combination chemotherapy was instituted with cyclophosphamide, adriamycin, vincristine and prednisone. After 3 cycles of chemotherapy, she showed no evidence of proteinuria and hematuria with clinical and radiological improvement of malignant lymphoma. Therefore we suggest of certain association between IgA nephropathy and non-Hodgkin's lymphoma by the observation of corresponding disease activity.
