A Case of Wegener's Granulomatosis with Acute Renal Failure and Pneumothorax Developed during Treatment with Immunosuppressive Agent.
- Author:
Sung Jae PARK
;
Hi Gun HA
;
Yang Wook KIM
;
Joo In KIM
;
Yeong Hoon KIM
;
Hye Kyoung YOON
- Publication Type:Case Report
- Keywords:
Wegener's granulomatosis;
Pneumothorax;
Acute renal failure
- MeSH:
Acute Kidney Injury*;
Autoimmune Diseases;
Cough;
Creatinine;
Diagnosis;
Drainage;
Dyspnea;
Fever;
Glomerulonephritis;
Hemoptysis;
Humans;
Immunosuppressive Agents;
Lung;
Pneumothorax*;
Respiratory System;
Thoracoscopy;
Thorax;
Vasculitis;
Wegener Granulomatosis*
- From:Korean Journal of Nephrology
1998;17(5):831-835
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Wegener's granulomatosis is characterized by necrotizing granulomatosis lesion of the respiratory tract, glomerulonephritis and frequently vasculitis involving other organs. The basic pathophysiologic mechanism of Wegener's granulomatosis is not defined yet. However, it may be suspected an autoimmune disease. We experienced a case of Wegener's granulomatosis which are associated with acute renal failure and pneumothorax. The patient suffered from hemoptysis, fever and cough. Despite antibiotic therapy, symtoms did not improved and multiple varying sized nodules were aggravated on chest roentogenogram and serum creatinine elevated 3.4mg/dl. After diagnosis using video associated thoracoscopic surgery, the patient was treated with cyclophsphamide, glucocorticoid and sulfamethoxasole-trimethoprime. With the combination therapy, the patient felt completely well and chest roentogenogram showed lungs were improved and serum creatinine was normal. The patient was readmitted because of right pleuritic pain and dyspnea 15 day after discharge. The patient was developed a right pneumothorax. The lung was easily expanded by intercostal tube drainage with a one way valve. The patient has been treated as an out- patient with immunosuppressive agents continously.
