Abdominal Aortic Calcification is Associated with Diastolic Dysfunction, Mortality, and Nonfatal Cardiovascular Events in Maintenance Hemodialysis Patients.
10.3346/jkms.2012.27.8.870
- Author:
Hye Eun YOON
1
;
Sungjin CHUNG
;
Hyun Chul WHANG
;
Yu Ri SHIN
;
Hyeon Seok HWANG
;
Hyun Wha CHUNG
;
Cheol Whee PARK
;
Chul Woo YANG
;
Yong Soo KIM
;
Seok Joon SHIN
Author Information
1. Division of Nephrology, Department of Internal Medicine, Incheon St. Mary's Hospital, Incheon, Korea. imkidney@catholic.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Hemodialysis;
Vascular Calcification;
Ventricular Dysfunction, Left;
Cardiovascular Diseases
- MeSH:
Adult;
Age Factors;
Aged;
Aged, 80 and over;
Aorta, Abdominal;
Blood Flow Velocity;
Blood Pressure;
Calcinosis/*etiology;
Cardiovascular Diseases/*complications;
Disease-Free Survival;
Echocardiography;
Female;
Follow-Up Studies;
Humans;
Kaplan-Meier Estimate;
Kidney Failure, Chronic/*complications/mortality;
Male;
Middle Aged;
Predictive Value of Tests;
Prognosis;
Regression Analysis;
Renal Dialysis;
Risk Factors;
Tomography, X-Ray Computed;
Ventricular Dysfunction, Left/complications/*physiopathology
- From:Journal of Korean Medical Science
2012;27(8):870-875
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study evaluated the significance of aortic calcification index (ACI), an estimate of abdominal aortic calcification by plain abdominal computed tomography (CT), in terms of left ventricular (LV) diastolic dysfunction, mortality, and nonfatal cardiovascular (CV) events in chronic hemodialysis patients. Hemodialysis patients who took both an abdominal CT and echocardiography were divided into a low-ACI group (n = 64) and a high-ACI group (n = 64). The high-ACI group was significantly older, had a longer dialysis vintage and higher comorbidity indices, and more patients had a previous history of CV disease than the low-ACI group. The ACI was negatively correlated with LV end-diastolic volume or LV stroke volume, and was positively correlated with the ratio of peak early transmitral flow velocity to peak early diastolic mitral annular velocity (E/E' ratio), a marker of LV diastolic function. The E/E' ratio was independently associated with the ACI. The event-free survival rates for mortality and nonfatal CV events were significantly lower in the high-ACI group compared with those in the low-ACI group, and the ACI was an independent predictor for all-cause deaths and nonfatal CV events. In conclusion, ACI is significantly associated with diastolic dysfunction and predicts all-cause mortality and nonfatal CV events in hemodialysis patients.
