Coexistence of Chronic Lymphocytic Thyroiditis with Papillary Thyroid Carcinoma: Clinical Manifestation and Prognostic Outcome.
10.3346/jkms.2012.27.8.883
- Author:
Jun Soo JEONG
1
;
Hyun Ki KIM
;
Cho Rok LEE
;
Seulkee PARK
;
Jae Hyun PARK
;
Sang Wook KANG
;
Jong Ju JEONG
;
Kee Hyun NAM
;
Woong Youn CHUNG
;
Cheong Soo PARK
Author Information
1. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea. jungjongj@yuhs.ac
- Publication Type:Original Article
- Keywords:
Chronic Lymphocytic Thyroiditis;
Papillary Thyroid Carcinoma;
Recurrence;
Prognostic Outcome
- MeSH:
Adult;
Carcinoma/complications/*diagnosis/surgery;
Carcinoma, Papillary/complications/*diagnosis/surgery;
Disease-Free Survival;
Female;
Follow-Up Studies;
Hashimoto Disease/complications/mortality/*pathology;
Humans;
Lymphatic Metastasis;
Male;
Middle Aged;
Neoplasm Staging;
Odds Ratio;
Predictive Value of Tests;
Prognosis;
Recurrence;
Sex Factors;
Survival Rate;
Thyroid Neoplasms/complications/*diagnosis/surgery;
Thyroidectomy
- From:Journal of Korean Medical Science
2012;27(8):883-889
- CountryRepublic of Korea
- Language:English
-
Abstract:
The study aimed to identify the clinical characteristics of coexisting chronic lymphocytic thyroiditis (CLT) in papillary thyroid carcinoma (PTC) and to evaluate the influence on prognosis. A total of 1,357 patients who underwent thyroid surgery for PTC were included. The clinicopathological characteristics were identified. Patients who underwent total thyroidectomy (n = 597) were studied to evaluate the influence of coexistent CLT on prognosis. Among the total 1,357 patients, 359 (26.5%) had coexistent CLT. In the CLT group, the prevalence of females was higher than in the control group without CLT (P < 0.001). Mean tumor size and mean age in the patients with CLT were smaller than without CLT (P = 0.040, P = 0.047, respectively). Extrathyroidal extension in the patients with CLT was significantly lower than without CLT (P = 0.016). Among the subset of 597 patients, disease-free survival rate in the patients with CLT was significantly higher than without CLT (P = 0.042). However, the multivariate analysis did not reveal a negative association between CLT coexistence and recurrence. Patients with CLT display a greater female preponderance, smaller size, younger and lower extrathyroidal extension. CLT is not a significant independent negative predictive factor for recurrence, although presence of CLT indicates a reduced risk of recurrence.
