Scleroderma Treated with Penicillamine-D.
- Author:
Young Chan CHOI
;
Yoon Kee PARK
;
Sung Nack LEE
- Publication Type:Original Article
- MeSH:
Chronic Disease;
Connective Tissue;
Humans;
Pulmonary Fibrosis;
Scleroderma, Diffuse;
Scleroderma, Localized;
Scleroderma, Systemic;
Sclerosis;
Skin;
Thorax
- From:Korean Journal of Dermatology
1977;15(4):483-492
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Scleroderma is an incidious and chronic disease of unknown cause. The clinical picute of scleroderma is characterized by the apperance of circumscribed of diffuse, hard, smooth, ivory colored areas that are immobile upon upon the underlying tissues. It may be classified to as a localized form (morphea) and a systemic scleroderma or progressive systemic sclerosis (PSS) which is characterized by diffuse involvment of the connective tissue of the skin and certain intemal organs. The authors observed 3 cases of PSS and 6 cases of morphea. They have complained of marked sclerosis or thickening of skin or slowly developing dyspneadue to interstitial pulmonary fibrosis which were confirmed by chest X-ray. Recently, penicillamine-D has been advocated as a beneficial agent in scleroderma by Asboe-Hansen. therefore, penicillamine-D was administered to the above patients. Two of PSS were markedly improved with normal skin softness. Two of morphea were also moderately improved. Other patients remained stationary or no effect.
