Effects of a Combination of Nicardipine and Alfentanil on Hemodynamic Response after Endotracheal Intubation.
10.4097/kjae.2005.48.6.587
- Author:
Chang Mo KIM
1
;
Sung Tae JEONG
;
Seok Jai KIM
;
Hong Beom BAE
;
Jeong Il CHOI
;
Seong Wook JEONG
;
Sung Su CHUNG
;
Kyung Yeon YOO
;
Chang Young JEONG
;
Myung Ha YOON
Author Information
1. Department of Anesthesiology and Pain Medicine, Medical School, Chonnam National University, Gwangju, Korea. mhyoon@chonnam.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
alfentanil;
nicardipine;
intubation;
systolic blood pressure;
diastolic blood pressure;
heart rate
- MeSH:
Alfentanil*;
Blood Pressure;
Heart Rate;
Hemodynamics*;
Humans;
Intubation;
Intubation, Intratracheal*;
Nicardipine*
- From:Korean Journal of Anesthesiology
2005;48(6):587-591
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The present study was designed to examine the effect of a combination of nicardipine and low dose alfentanil on hemodynamic response following endotracheal intubation. METHODS: Thirty patients (20-65 yr) were assigned randomly to receive nicardipine (N: 20microgram/kg) or a combination of nicardipine and low dose of alfentanil (NA: nicardipine 10microgram/kg and alfentanil 5microgram/kg). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured at 1, 2 min after anesthetic induction, and every minute for 5 min after intubation. RESULTS: The magnitude of increases in SBP and DBP were non-significantly smaller in the NA group than in the N group, and increase in HR were significantly lower in the NA group. CONCLUSIONS: These results indicate that the nicardipine with alfentanil combination was more effective than nicardipine alone at attenuating blood pressure and heart rate increases following intubation.
