Korean Medication Algorithm for Bipolar Disorder 2014: Safety and Tolerability.
- Author:
Inki SOHN
1
;
Moon Doo KIM
;
Jung Goo LEE
;
Bo Hyun YOON
;
Jong Hyun JEONG
;
Se Hoon SHIM
;
Young Sup WOO
;
Jeong Suk SEO
;
Young Chul SHIN
;
Kyong Joon MIN
;
Won Myong BAHK
;
Duk In JON
Author Information
1. Department of Psychiatry, Keyo Hospital, Keyo Medical Foundation, Uiwang, Korea.
- Publication Type:Original Article
- Keywords:
Bipolar disorder;
Weight gain;
Non-adherence;
Lamotrigine;
Hyperprolactinemia;
Genetic counselling;
Algorithm
- MeSH:
Advisory Committees;
Bipolar Disorder*;
Exanthema;
Expert Testimony;
Food Habits;
Hope;
Hyperprolactinemia;
Weight Gain
- From:Korean Journal of Psychopharmacology
2014;25(4):161-167
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The complexity of the treatment for bipolar disorder is often caused by the presence of side effects of various psychiatric medications. In particular, weight gain and metabolic syndrome are currently major concerns in the medication for bipolar disorders. Therefore, we undertook a survey of expert opinion to help make clinical decisions in these special situations. METHODS: A written survey which asked about treatment strategies in the safety and tolerability was prepared; 1) weight gain, 2) antipsychotic related hyperprolactinemia, 3) lamotrigine related skin rash, 4) treatment non-adherence, and 5) genetic counselling. Treatment options were scored using a 9-point scale for rating appropriateness of clinical decisions in some issues. In other issues, experts were asked to choose to determine the ranking of preferences on the list. Sixty-four experts of the review committee completed the survey. We classified the expert opinions about preferences by chi2 test. RESULTS: Experts preferred behavioral and diet modification for weight gain, switching to prolactin-sparing-antipsychotics for antipsychotic-induced hyperprolactinemia, reducing dose of lamotrigene for its related benign skin rash, and prescribing once a day for treatment adherence. CONCLUSION: With the limitation of expert opinion, authors hope that the results of this study provide valuable information to make clinical decision about the treatment of bipolar disorder in the complicated situations.
