Effect of Trans-4-Aminomethylcyclohexanecarboxylic Acid on the Proliferation and Melanization in Cultured Normal Human Melanocytes.
- Author:
Seong Jun SEO
1
;
Sung Hyun CHO
;
Wan Ik CHO
;
Mi Sook JUNG
;
Sung Wook RO
;
Myeung Nam KIM
;
Chang Kwun HONG
Author Information
- Publication Type:Original Article
- Keywords: Melanocytes; Tranexamic acid; UVB
- MeSH: Dendrites; Foreskin; Humans*; Melanins; Melanocytes*; Monophenol Monooxygenase; Morphogenesis; Pigmentation; Tranexamic Acid
- From:Annals of Dermatology 2007;19(2):60-67
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Trans-4-aminomethylcyclohexanecarboxylic acid (tranexamic acid) has recently been reported to inhibit prostaglandin synthesis and hinder the pigmentation caused after UV radiation. OBJECTIVE: we evaluated the influence of tranexamic acid on the viability, morphogenesis and melanization of cultured normal human melanocytes. METHOD: The cultured melanocytes from neonatal foreskin were exposed to UVB 20mJ/cm2, then treated with tranexamic acid [0.05microgram/ml, 0.05microgram/ml, and 0.5microgram/ml]. After 24 hours, the viability of melanocytes and the melanin concentration was measured. The number and length of the melanocytes' dendrites, and the expression level of tyrosinase, TRP-1 and TRP-2 were also evaluated. RESULTS: The viability of the melanocytes was decreased by tranexamic acid in a dose dependent manner (p<0.05). The increased melanin synthesis by UVB irradiation was decreased by tranexamic acid in a dose dependent manner (p<0.05). Also, the increased expressions of TRP-1, TRP-2 and tyrosinase after exposure to UV were statistically decreased by tranexamic acid in a dose dependent manner (p<0.05). CONCLUSION: tranexamic acid may prevents UVB induced pigmentation.
