Age Specific Free PSA to Total PSA Ratio in Normal Korean Men.
- Author:
Soon Saeng KWON
1
;
Heung Jae PARK
;
Chil Hun KWON
Author Information
1. Department of Urology, Sungkyunkwan University, College of Medicine, Kangbuk Samsung Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Prostate specific antigen;
Prosate carcinoma;
Free PSA;
Total PSA
- MeSH:
Aged;
Humans;
Male;
Multiple Endocrine Neoplasia Type 1;
Prostate;
Prostate-Specific Antigen;
Prostatic Neoplasms;
Radioimmunoassay;
Reference Values;
Sensitivity and Specificity
- From:Korean Journal of Urology
1997;38(10):1063-1066
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Prostate specific antigen (PSA) is known as the most sensitive marker for detecting prostate carcinoma (CaP). Nevertheless, PSA testing lacks sufficient sensitivity and specificity to be considered the perfect tumor marker for the detection of early prostate cancer. PSA exists in the serum in several molecular forms; free PSA and complexed PSA (PSA complexed to alpha-1-antichymotrypsin or a-2-macrogloburin or inter-alpha -trypsin inhibitor). It has been suggested that analysis of level of free to total PSA ratio improves specificily of PSA assays in the early detection of prostate carcinoma. We measured free PSA and total PSA of 367 healthy men aged from 30 to 79 years old using radioimmunoassay (PSA-RIACT and FPSA-RIACT kit) in order to know the normal range of PSA, free PSA and free PSA to total PSA ratio. The mean free to total PSA ratio in normal Korean men is 0.31+/-0.14 and there is no correlation with patient age.
