Prevalence of Osteoporosis in Korean Patients with Chronic Obstructive Pulmonary Disease and Their Health-related Quality of Life According to the Korea National Health and Nutrition Examination Survey 2008–2011.
10.11005/jbm.2017.24.4.241
- Author:
Sang Hee LEE
1
;
Hye Young KWON
Author Information
1. Department of Internal Medicine, Wonkwang University Sanbon Hospital, Gunpo, Korea.
- Publication Type:Original Article
- Keywords:
Bone density;
Osteoporosis;
Pulmonary disease chronic obstructive;
Quality of life
- MeSH:
Absorptiometry, Photon;
Body Mass Index;
Bone Density;
Education;
Family Characteristics;
Female;
Femur;
Femur Neck;
Humans;
Korea*;
Male;
Multivariate Analysis;
Nutrition Surveys*;
Osteoporosis*;
Prevalence*;
Pulmonary Disease, Chronic Obstructive*;
Quality of Life*;
Risk Factors;
Smoke;
Smoking;
Spine
- From:Journal of Bone Metabolism
2017;24(4):241-248
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: In this study, we evaluated the prevalence of osteoporosis, risk factors associated with osteoporosis, and health-related quality of life (HRQOL) in clinically stable chronic obstructive pulmonary disease (COPD) patients. METHODS: A total of 1,081 COPD patients were recruited from the Korea National Health and Nutrition Examination Survey (KNHANES) from July 2008 to May 2011. Bone mineral densities at the lumbar spine, femoral neck, and total proximal femur were measured using dual energy X-ray absorptiometry. HRQOL was assessed using the EuroQOL-5 dimensions (EQ-5D) questionnaire. To identify factors associated with osteoporosis and HRQOL in patients with COPD, multivariate regression analyses was performed. RESULTS: Of the 1,081 COPD patients, 191 (17.7%) were diagnosed with osteoporosis. There were significant differences in age, sex, smoking status, education level, house income, and body mass index (BMI) between the osteoporotic and non-osteoporotic groups. COPD patients with osteoporosis had significantly lower EQ-5D scores than the controls. In multivariate analyses, older age (odds ratio [OR]=1.10, P < 0.001) was risk factor for osteoporosis. And patients of male sex (OR=0.06, P < 0.001), high house income (OR=0.75, P=0.045), and high BMI (OR=0.74, P < 0.001) were less likely to have osteoporosis. In addition, osteoporosis was associated with poor HRQOL (β=−0.21, P=0.023). CONCLUSIONS: The prevalence of osteoporosis in COPD patients based on the 2008 to 2011 KNHANES data were relatively lower than that in physician-diagnosed COPD patients. In these COPD patients, older age, female sex, low household income, and low BMI increased the risk for osteoporosis.
