The Effect of Topically Applied Sodium-hyaluronic acid(Na-HA) on Corneal Epithelial Healing.
- Author:
Jang Hyun CHUNG
1
;
Eun Ah KIM
;
Kae Rang KWON
;
Chung Sook AHN
Author Information
1. Department of Ophthalmology, Medical Research Center, Ewha Womans University, Seoul, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Corneal epithelium;
Healing rate;
1% Na-hyaluronic acid;
Morphometry
- MeSH:
Anti-Bacterial Agents;
Cornea;
Epithelium, Corneal;
Humans;
Linear Models;
Wound Healing
- From:Journal of the Korean Ophthalmological Society
1996;37(6):921-926
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To evaluate the effect of Na-hyaluronic acid (Na-HA) on corneal epithelial wound healing, twenty admitted patients (twenty-four eyes) with corneal epithelial abrasion were randomly divided into 2 groups. 1% Na-HA was given 4 times daily to 12 treated eyes while 12 control cases received antibiotic ointment therapy. Epithelial defect area was photodocumented by 6-12 hours interval and individual healing rates were calculated by linear regression analysis. The healing rate of 1% Na-HA treated cornea was 1.02 +/- 0.26mm2/hour and that of the control eyes was 0.67 +/- 0.19 mm/hour(p<0.05). The result suggests that topically applied Na-HA enhances epithelial re~surfacing when compared to the antibiotics ointment.
