Association between beta2 adrenoceptor polymorphisms and atopy/serum IgE in asthmatic patients.
10.4046/trd.1999.46.6.826
- Author:
Sin Hyung LEE
1
;
Jae Jeong SHIM
;
Yong Koo KANG
;
Hye Cheol JEONG
;
Kyung Kyu KIM
;
Young Hwan KWON
;
Je Hyeong KIM
;
Sung Yong LEE
;
So Ra LEE
;
Sang Youb LEE
;
Jae Youn CHO
;
Kwang Ho IN
;
Se Hwa YOO
;
Kyung Ho KANG
Author Information
1. Department of Internal Medicine, Korea University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Asthma;
Beta-2 adrenergic receptor;
Polymorphism;
Atopy;
IgE
- MeSH:
Alleles;
Asthma;
Humans;
Immunoglobulin E*;
Phenotype;
Receptors, Adrenergic;
Receptors, Adrenergic, beta-2;
Skin
- From:Tuberculosis and Respiratory Diseases
1999;46(6):826-835
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The beta2 adrenergic receptor (beta2 AR) polymorphisms occurring at amino acid position 16 (Arg to Gly), 27 (Gln to Glu), 34 (Val to Met), and 164 (Thr to Ile) are known to be functionally relevant and also disease-modifying in subjects with asthma. However the contribution of these polymorphisms to the development of the asthmatic phenotype or other markers for allergic disease remains to be established. METHODS: 109 patients with bronchial asthma and 42 healthy person were included. Serum total IgE, allergen specific IgE, and skin prick test were performed to all of the subjects. beta2 AR polymorphisms were checked by mutated allele specific amplification (MASA) method. RESULTS: The results were as follows. The frequencies of beta2 AR polymorphisms in asthmatic patients and healthy person were not statistically different(p>0.05). There was no association between beta2 AR polymorphisms of amino acid position 16, 27, 34 and the existence of atopy among asthmatic patients (p>0.05). Between asthmatic patients with or without elevated IgE level and beta2 AR polymorphisms of amino acid position 16, 27, 34, there was no statistically significant association(p>0.05). CONCLUSION: There was no difference in frequency of the beta2 AR polymorphism between asthmatic patients and healthy person. In the bronchial asthma, association of beta2 AR polymorphism and atopy/serum total IgE was not found.
