In Situ Follicular Lymphoma Developed after Hodgkin Lymphoma.
10.4132/KoreanJPathol.2011.45.S1.S53
- Author:
Ho Sung PARK
;
Sang Jae NOH
;
Jae Yong KWAK
;
Eun Kee SONG
;
Myung Hee SOHN
;
Ho LEE
;
Woo Sung MOON
;
Kyu Yun JANG
- Publication Type:Case Report
- Keywords:
Lymphoma;
Bcl-2 protein;
Preneoplastic conditions
- MeSH:
Biopsy;
Follow-Up Studies;
Germinal Center;
Hodgkin Disease;
Humans;
Lymph Nodes;
Lymphoid Tissue;
Lymphoma;
Lymphoma, Follicular;
Precancerous Conditions
- From:Korean Journal of Pathology
2011;45(Suppl 1):S53-S57
- CountryRepublic of Korea
- Language:English
-
Abstract:
In situ follicular lymphoma is a newly defined entity among the lymphoid neoplasms and is defined as architecturally normal-appearing lymph nodes and other lymphoid tissues that have one or more follicles that demonstrate bcl-2 overexpressing centrocytes and centroblasts, with or without a monomorphic cytologic appearance suggestive of follicular lymphoma. Here we present a case of in situ follicular lymphoma diagnosed during the follow-up after a complete response to the treatment of lymphocyte-rich classical Hodgkin's lymphoma. In our case, because only a few germinal centers contained bcl-2 overexpressing cells, we missed the diagnosis of in situ follicular lymphoma in the initial histological examination. We could establish the diagnosis only after performing bcl-2 immunostaining in the sequential biopsy. Therefore, we recommend that careful histological examination along with bcl-2 immunostaining is needed in patients with suspicious clinical findings.
