A Clinical Usefulness of Premedication with Hyoscine N-butyl Bromide in Colonoscopy.
- Author:
Eun Ok KIM
1
;
Suck Ho LEE
;
Duk Su KIM
;
Chang Kyun LEE
;
Tae Hoon LEE
;
Il Kwun CHUNG
;
Sang Heum PARK
;
Sun Joo KIM
Author Information
1. Department of Internal Medicine, Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea. ygun99@hanmail.net
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Colonoscopy;
Premedication;
Antispasmodics;
Hyoscine-N-butyl bromide
- MeSH:
Adenoma;
Colonoscopy;
Humans;
Injections, Intramuscular;
Intubation;
Parasympatholytics;
Polyps;
Premedication;
Prospective Studies;
Scopolamine Hydrobromide;
Sodium Chloride;
Spasm
- From:Korean Journal of Gastrointestinal Endoscopy
2010;41(1):10-15
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: We conducted a prospective, randomized, double-blinded, placebo-controlled trial to investigate the effect of hyoscine-N-butyl bromide during colonoscopy. METHODS: A total of 133 patients undergoing colonoscopy were randomized to receive either 20 mg of hyoscine-N-butyl bromide (n=70) or normal saline solution (n=63) via intramuscular injection as premedication. RESULTS: The mean cecal intubation time and withdrawal time in the hyoscine-N-butyl bromide group were significantly shorter than those of the control group (5.26+/-2.78 min vs. 6.74+/-4.89 min; p=0.032, 5.42+/-1.54 min vs. 6.18+/-2.54 min; p=0.038, each). The spasm grade in the hyoscine-N-butyl bromide group was significantly lower than that of the control group (p<0.001). No significant differences were found in the polyp detection rate (15.7% vs. 28.6%; p=0.073) and adenoma detection rate (10.0% vs. 15.9%; p=0.311). Difficulty of colonoscopy for the endoscopists and nurses (p=0.853; p=0.732), the patient's comfort (p=0.891) and the patient's willingness to repeat colonoscopy (85.7% vs. 82.5%; p=0.932) were also similar in both groups. CONCLUSIONS: Premedication with intramuscularly administered hyoscine-N-butyl bromide do not demonstrate any additional benefits except reducing the colonoscopy insertion time.
