Predictive factors and the prognosis of recurrence of colorectal cancer within 2 years after curative resection.
10.4174/astr.2014.86.3.143
- Author:
Jong Pil RYUK
1
;
Gyu Seog CHOI
;
Jun Seok PARK
;
Hye Jin KIM
;
Soo Yeun PARK
;
Ghil Suk YOON
;
Soo Han JUN
;
Yong Chul KWON
Author Information
1. Colorectal Cancer Center, Kyungpook National University Medical Center, Kyungpook National University School of Medicine, Daegu, Korea. kyuschoi@mail.knu.ac.kr
- Publication Type:Original Article
- Keywords:
Colorectal neoplasms;
Recurrence interval;
Risk factors;
Recurrence;
Survival
- MeSH:
Colorectal Neoplasms*;
Humans;
Liver;
Lung;
Multivariate Analysis;
Prognosis*;
Recurrence*;
Risk Factors;
Survival Rate
- From:Annals of Surgical Treatment and Research
2014;86(3):143-151
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Because predicting recurrence intervals and patterns would allow for appropriate therapeutic strategies, we evaluated the clinical and pathological characteristics of early and late recurrences of colorectal cancer. METHODS: Patients who developed recurrence after undergoing curative resection for colorectal cancer stage I-III between January 2000 and May 2006 were identified. Early recurrence was defined as recurrence within 2 years after primary surgery of colorectal cancer. Analyses were performed to compare the clinicopathological characteristics and overall survival rate between the early and late recurrence groups. RESULTS: One hundred fifty-eight patients experienced early recurrence and 64 had late recurrence. Multivariate analysis revealed that the postoperative elevation of carbohydrate antigen 19-9 (CA 19-9), venous invasion, and N stage correlated with the recurrence interval. The liver was the most common site of early recurrence (40.5%), whereas late recurrence was more common locally (28.1%), or in the lung (32.8%). The 5-year overall survival rates for early and late recurrence were significantly different (34.7% vs. 78.8%; P < 0.001). Survival rates after the surgical resection of recurrent lesions were not different between the two groups. CONCLUSION: Early recurrence within 2 years after surgery was associated with poor survival outcomes after colorectal cancer recurrence. An elevated postoperative CA 19-9 level, venous invasion, and advanced N stage were found to be significant risk factors for early recurrence of colorectal cancer.
