Diagnostic Ability of Tc-99m MIBI SPECT in Coronary Artery Diseases is not Affected by the Degree of Exercise.
- Author:
Kyu Bo LEE
;
Shung Chull CHAE
;
Kyung Ah CHUN
;
Jong Soo KIM
;
Sang Woo LEE
;
Jaetae LEE
;
Do Young KANG
;
Yong Keun CHO
- Publication Type:Original Article
- Keywords:
Exercise;
Tc-99m MIBI;
Myocardium;
Perfusion;
SPECT;
Coronary artery disease;
Diagnosis
- MeSH:
Cardiac Catheterization;
Cardiac Catheters;
Coronary Artery Disease*;
Coronary Stenosis;
Coronary Vessels*;
Depression;
Diagnosis;
Electrocardiography;
Exercise Test;
Female;
Heart Rate;
Humans;
Male;
Myocardial Ischemia;
Myocardium;
Perfusion;
Prevalence;
Sensitivity and Specificity;
Tomography, Emission-Computed, Single-Photon*
- From:Korean Journal of Nuclear Medicine
1999;33(1):40-48
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The sensitivity of ST-depression in the electrocardiogram during exercise is influenced by the level of efforts. However, unlike the prevalence of ST-depression on exercise ECG, the degree of exercise is reported to do not influence the diagnostic ability of myocardial perfusion scan. Furthermore, the relation between the prevalence of myocardial ischemia and effort is still controversial. We evaluated the effect of the degree of exercise on the ability of SPECT imaging to detect coronary artery stenosis. MATERIALS AND METHODS: The patient population was comprised of 111 patients (73 men and 38 women, mean age 56 years) who underwent an exercise test in conjunction with Tc-99m MIBI and cardiac catheterization within 3 months apart each other. The degree of exercies was classified into four groups according to the percentage of maximal predicted heart rate. The sensitivity and specificity was compared between each group. RESULTS: The overall diagnostic sensitivity was significantly higher with Tc-99m MIBI SPECT than exercise ECG. The specificity was not significantly different between two tests. Sensitivity and specificity of Tc-99m MIBI was not different between four groups. Sensitivity for individual coronary stenosis seemed to be lower in subjects who had premature termination of exercise due to early appearance of ST depression. CONCLUSION: These RESULTS suggest that the overall diagnostic sensitivity of Tc-99m MIBI myocardial perfusion SPECT is not significantly affected by the degree of exercise in stable patients undergoing symptom-limited treadmill exercise testing. Myocardial perfusion SPECT imaging should be added to routine exercise stress testing for the detection of coronary artery disease.
