A Case of Hashimoto's Thyroiditis with Transient T3-Thyrotoxicosis Induced by Hydatidiform Mole.
10.3803/jkes.2005.20.3.294
- Author:
Ji Youn YOO
1
;
Hong Ju MOON
;
Cheol Young PARK
;
Seong Jin LEE
;
In Kyung JEONG
;
Eun Gyung HONG
;
Gi Weon OH
;
Hyeon Kyu KIM
;
Doo Men KIM
;
Jae Myung YOO
;
Sung Hee IHM
;
Moon Gi CHOI
;
Hyung Joon YOO
;
Sung Woo PARK
;
Soo Kee MIN
Author Information
1. Department of lnternal Medicine, College of Medicine, Hallym University, Chunchon, Korea.
- Publication Type:Case Report
- Keywords:
Hashimoto's thyroiditis;
T3-thyrotoxicosis;
Hyperthyroidism;
GTD(Gestational trophoblastic disease);
H-mole
- MeSH:
Choriocarcinoma;
Chorion;
Female;
Gestational Trophoblastic Disease;
Glycoproteins;
Humans;
Hydatidiform Mole*;
Hyperthyroidism;
Hypothyroidism;
Placenta;
Pregnancy;
Receptors, Thyrotropin;
Thyroid Gland*;
Thyroiditis*
- From:Journal of Korean Society of Endocrinology
2005;20(3):294-298
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Human chorionic gonadotropin(HCG) is a member of the glycoproteins family synthesized by the placenta, which consists of 2 noncovalently joined subunits(alpha(alpha) and beta(beta)). The alpha- and beta-subunits have a structural homology with the alpha- and beta-subunits of TSH and LH. The thyrotropic action of HCG results from its structural similarity to TSH, so beta-HCG can bind to the TSH receptor in the thyroid gland. A high level of HCG accompanied by an increased thyroid hormone level, can be observed in gestational trophoblastic disease (GTD), such as a hydatidiform mole or a choriocarcinoma, but the clinical symptoms of hyperthyroidism are rarely observed. We experienced a case of Hashimoto's thyroiditis, where the patient was diagnosed with T3-thyrotoxicosis, which had initially been induced by excess beta-HCG due to an H-mole; after evacuation of the H-mole, the condition was diagnosed as hypothyroidism. It has been speculated that a patient with Hashimoto's thyroiditis could have hyperthyroidism, induced by beta-HCG, due to an H-mole
