Femoral bone structure in Otsuka Long-Evans Tokushima Fatty rats.
- Author:
Akira MINEMATSU
1
;
Tomoko HANAOKA
;
Yoshihiro TAKADA
;
Shunji OKUDA
;
Hidetaka IMAGITA
;
Susumu SAKATA
Author Information
1. Department of Physical Therapy, Faculty of Health Science, Kio University, 4-2-2 Umaminaka, Koryo-cho, Kitakatsuragi-gun, Nara 635-0832, Japan. a.minematsu@kio.ac.jp
- Publication Type:Original Article
- Keywords:
Cortical bone geometry;
Micro-CT;
Otsuka Long-Evans Tokushima Fatty (OLETF) rats;
Trabecular bone microstructure
- MeSH:
Animals;
Bone Density;
Diabetes Mellitus, Type 2;
Femur;
Models, Animal;
Rats*;
Rats, Inbred OLETF
- From:Osteoporosis and Sarcopenia
2016;2(1):25-29
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: Type 2 diabetes mellitus (T2DM) increases fracture risk despite normal to high levels of bone mineral density. Bone quality is known to affect bone fragility in T2DM. The aim of this study was to clarify the trabecular bone microstructure and cortical bone geometry of the femur in T2DM model rats. METHODS: Five-week-old Otsuka Long-Evans Tokushima Fatty (OLETF; n = 5) and Long-Evans Tokushima Otsuka (LETO; n = 5) rats were used. At the age of 18 months, femurs were scanned with micro-computed tomography, and trabecular bone microstructure and cortical bone geometry were analyzed. RESULTS: Trabecular bone microstructure and cortical bone geometry deteriorated in the femur in OLETF rats. Compared with in LETO rats, in OLETF rats, bone volume fraction, trabecular number and connectivity density decreased, and trabecular space significantly increased. Moreover, in OLETF rats, cortical bone volume and section area decreased, and medullary volume significantly increased. CONCLUSIONS: Long-term T2DM leaded to deterioration in trabecular and cortical bone structure. Therefore, OLETF rats may serve as a useful animal model for investigating the relationship between T2DM and bone quality.
