CAG Repeat Expansions in the Patients with Mood Disorder.
- Author:
Sung En SOHN
1
;
Shinn Won LIM
;
Soh Young LEE
;
Hye Zin HWANG
;
Dong Kyu JIN
;
Jeung Euy PARK
;
Doh Kwan KIM
;
Eyoung KIM
Author Information
1. Department of Psychiatry, Samsung Medical Center, College of Medicine, Sungkyunkwan University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Mood disorder;
Repeat expansion detection;
Trinucleotide repeat;
Mode of inheritance
- MeSH:
Anticipation, Genetic;
Bipolar Disorder;
Depressive Disorder, Major;
DNA;
Family Characteristics;
Health Services;
Humans;
MMPI;
Mood Disorders*;
Trinucleotide Repeat Expansion;
Trinucleotide Repeats;
Wills
- From:Journal of Korean Neuropsychiatric Association
2000;39(2):373-380
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The genetic facotrs have been suggested for the etiology of mood disorders but the mode of inheritance is complex. Increased severity and an earlier onset of the bipolar and major depressive disorder over generations within families(Anticipation) were reported. In order to test the hypothesis that trinucleotide repeat expansions underlie the genetic basis of Bipolar and major depressive disorders, we have analyzed the extent of CAG reapeats in genomic DNA from mood disorder patients. METHODS: 55 bipolar disorder, 67 major depressive disorder patients were recruited according to the DSM-III-R criteria. 89 normal controls were recruited from the medical personnel, students and the visitors to the health services center who had no history of psychiatric illness and show normal profile of MMPI. The genomic DNA of patients and controls was analyzed by use of the(CTG) 17 oligonucleotide and the repeat expansion detection(RED) method. The Mann-Whitney U test was used to compare the distribution of the number of CAG repeats among the groups. RESULTS: when the bipolar disorder, major depressive disorder patients were compared with the control group, no significant differences were observed. CONCLUSION: Our results do not support the hypothesis that expanding CAG repeats are causing the observed genetic anticipation in bipolar disorders and major depressive disorders.
