An Immunohistochemical Studcy of Estrogen-receptors and Progesterone-receptors Expression in Pyogenic Granuloma.
- Author:
Chang Geun CHO
1
;
Ae Ree KIM
;
Chil Hwan OH
;
Il Hwan KIM
Author Information
1. Department of Dermatology, Korea University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Pyogenic granuloma;
Estrogen receptor;
Progesteron receptor;
mmunohistochemistry
- MeSH:
Antibodies, Monoclonal;
Estrogens;
Female;
Gingival Diseases;
Granuloma, Pyogenic*;
Humans;
Male;
Mucous Membrane;
Pregnancy;
Progesterone;
Skin
- From:Korean Journal of Dermatology
1999;37(5):592-597
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Pyogenic granuloma(PG) is a common lesion of the skin and mucous membranes. The gingival lesion developed during pregnancy termed epulis gravidarum is identical to PG. Many articles have appeared in the literature pertaining to this lesion and its putative relationship to the hormonal changes of pregnancy. Several clinical features such as association with oral contraceptive use and regression after delivery, suggest that PG may be a hormone-sensitive lesion. OBJECTIVE: Our aim was to determine whether estrogen or progesterone might affect the development of PG. METHODS: We performed immunohistochemical staining by using a monoclonal antibodies to estrogen receptor(ER) and progesterone receptor(PR) in 15 PG(pregnant women; 4 cases, non-pregnant women; 5 cases, and men; 6 cases). RESULTS: All 15 PGs were negative for ER. However, for PR, the degree of staining was different according to the patient group; pregnant women(3 cases[75%]: weak positive, 1 case[25%]: strong positive), non-pregnant women(3 cases[60%]: weak positive), and men(6 cases[100%]: negative). CONCLUSION: Our results suggest that estrogen or progesterone may not directly involve in the formation of these lesions. Further studies are needed to determine whether the other factors are related to the pathogenesis of PG.
