The Anatomic Distribution and Pathological Characteristics of Prostate Cancer: A Mapping Analysis.
10.4111/kju.2006.47.6.578
- Author:
Taejin KANG
1
;
Cheryn SONG
;
Gee Hyun SONG
;
Gil Hyun SHIN
;
Dong Ik SHIN
;
Choung Soo KIM
;
Hanjong AHN
Author Information
1. Department of Urology and Biochemical Engineering, University of Ulsan College of Medicine, Seoul, Korea. hjahn@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Prostate neoplasms;
Maps;
Tumor burden
- MeSH:
Biopsy;
Ejaculatory Ducts;
Fluconazole;
Humans;
Male;
Prostate*;
Prostate-Specific Antigen;
Prostatectomy;
Prostatic Neoplasms*;
Seminal Vesicles;
Tumor Burden;
Weights and Measures
- From:Korean Journal of Urology
2006;47(6):578-585
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We mapped the location of prostate cancer in Korean men, and investigated the volume and tumor distribution in relation to clinicopathological variables. MATERIALS AND METHODS: The volume of cancer and the anatomic location of each tumor foci were determined from 186 radical prostatectomy specimens, which were digitized to fit into a prototype prostate model. Using the computer-based digital images, the zonal cancer volume and distributional frequency were analyzed with respect to the clinical and pathological parameters, which were demonstrated in gray scales. RESULTS: The preoperative serum prostate-specific antigen (PSA) level ranged from 2.0 to 38.9ng/ml. The mean cancer volume of the 186 specimens was 4.5ml (median 1.9ml, range 0.01-37.7). The impalpable cancers were located more anteriorly and in the transition zone, and were also were smaller in volume (2.7ml vs. 5.5ml, p=0.004) than the palpable cancers. Cancers with seminal vesicle invasion were located more medially in the peripheral zone, and were larger in volume than organ-confined cancers or cancers with extracapsular extension (13.2ml vs. 3.0ml, p<0.001). For Gleason scores of 2-6, 7, and 8-10, the mean cancer volumes were 2.2, 3.7 and 8.2ml, respectively (p<0.001). High grade cancers were located more medially in the peripheral zone, especially when approaching the apex. CONCLUSIONS: T1c cancers are located more anteriorly and in the transition zone; therefore, inclusion of these areas for targeted biopsy may help to improve the detection of cancer in patients with elevated PSA levels and impalpable prostate cancer. A medial location of seminal vesicle invasive cancers may imply an ejaculatory ducts route of invasion rather than a direct extracapsular extension.
