Correlation of Caveolin-1 Expression on Tissue Microarray with Prognosis in Renal Cell Carcinoma.
10.4111/kju.2006.47.6.607
- Author:
Yong Yeun WON
1
;
Hee Jae JOO
;
Dae Sung CHO
;
Kyung Sik SEO
;
Byung Cheol AHN
;
Ki Hoon KIM
;
Se Joong KIM
Author Information
1. Department of Urology, Ajou University School of Medicine, Suwon, Korea. sejoong@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Caveolin-1;
Tissue microarray;
Prognosis;
Renal cell carcinoma
- MeSH:
Antibodies;
Carcinoma, Renal Cell*;
Caveolin 1*;
Humans;
Multivariate Analysis;
Neoplasm Metastasis;
Nephrectomy;
Prognosis*
- From:Korean Journal of Urology
2006;47(6):607-613
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We investigated the relationship between the expression of caveolin-1, using a tissue microarray (TMA), and the prognosis of patients with renal cell carcinoma (RCC). MATERIALS AND METHODS: TMA sections of formalin-fixed, paraffin-embedded tissues of RCC from 82 patients, who had undergone radical nephrectomy, were stained immunohistochemically with specific antibodies against caveolin-1. The caveolin-1 immunostaining was semi-quantitatively estimated based on intensity. The expression pattern of caveolin-1 was compared with the clinicopathological variables. RESULTS: The expression of caveolin-1 was significantly correlated with tumor size (p=0.002), TNM stage (p<0.001), T stage (p=0.001), M stage (p=0.004), grade (p=0.028) and metastasis (p<0.001), and was also significantly higher in clear cell than non-clear cell RCC (p<0.001). The survival of patients with higher caveolin-1 expression was significantly worse than that of patients with lower caveolin-1 expression (p=0.001). Univariate analyses were able to identify all variables, including caveolin-1 expression as significant prognostic factors for cancer-specific survival; multivariate analyses indicated that TNM stage, M stage and grade were independent prognostic factors. Caveolin-1 expression was not an independent factor. CONCLUSIONS: The increased expression of caveolin-1 is associated with tumor size, stage, grade, metastasis and a worse prognosis in RCC, which suggests that caveolin-1 may be important in the progression of RCC.
