The Review of Epidemiological investigation of Leprosy by Using Polymerase Chain Reaction.
- Author:
Jong Pill KIM
1
;
Young Hoon KO
Author Information
1. Institute for Leprosy Research, Korean Hansen Welfare Association, Korea. dr_jpkim@hotmail.com
- Publication Type:Original Article
- Keywords:
Epidemiology;
Leprosy;
Mycobacterium leprae;
genotyping;
PCR
- MeSH:
Diagnosis;
DNA;
Drug Resistance;
Epidemiologic Studies;
Epidemiology;
Humans;
Leprosy*;
Mycobacterium leprae;
Polymerase Chain Reaction*;
Recurrence;
Tandem Repeat Sequences
- From:Korean Leprosy Bulletin
2005;38(1):15-24
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Studies about Mycobacterium leprae DNA in samples from leprosy patients are included in the diagnosis of leprosy, the study of drug resistance and the epidemiological investigation. Recently, application of the polymerase chain reaction to epidemiological study of leprosy is introduced. PCR-based typing would be of great value for epidemiological investigation; to identify infectious source of leprosy, understand transmission pattern, and distinguish between relapse & re-infection. Variable TTC DNA repeats in non-coding region and 6bp(ACATCG) tandem repeats in rpoT gene revealed PCR products of different size may be useful to investigate the epidemiology of leprosy.
