N-Acetylcysteine Improves Pancreatic Microcirculation and Alleviates the Severity of Acute Necrotizing Pancreatitis.
- Author:
Bing Qing DU
1
;
Yue Ming YANG
;
Yong Hua CHEN
;
Xu Bao LIU
;
Gang MAI
Author Information
- Publication Type:Original Article
- Keywords: Acetylcysteine; Acute necrotizing pancreatitis; Pancreatic microvascular perfusion; Laser-Doppler flowmetry; Taurocholic acid
- MeSH: Acetylcysteine; Animals; Atrial Natriuretic Factor; Edema; Infusions, Intravenous; Laser-Doppler Flowmetry; Microcirculation; Necrosis; Pancreas; Pancreatic Ducts; Pancreatitis, Acute Necrotizing; Perfusion; Rats; Sodium; Taurocholic Acid
- From:Gut and Liver 2013;7(3):357-362
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: To investigate the beneficial effect of N-Acetylcysteine (NAC) on pancreatic microvascular perfusion in acute necrotizing pancreatitis (ANP). METHODS: Fifty-four rats were divided into a control group, an ANP group and an NAC-treated group. The ANP model was established by a retrograde injection of 3% sodium taurocholate into the pancreatic duct. The NAC-treated group received an intravenous infusion of NAC just 2 hours before and 30 minutes after the induction of ANP. The pancreatic microvascular perfusion was measured with laser Doppler flowmetry and pancreatic samples were collected for histological examination. RESULTS: The microvascular perfusion in the NAC-treated group decreased slightly and exhibited a significant increase compared to the ANP group (p<0.01). A pathological examination revealed that edema and inflammatory infiltration decreased, and the hemorrhaging and necrosis of the pancreas were significantly reduced. CONCLUSIONS: NAC could improve pancreatic microvascular perfusion and alleviate the severity of sodium taurocholate-induced ANP, possibly representing a new therapeutic approach to prevent the progression of ANP.
