Expression of p53, bcl-2 Protein in Colorectal Cancer and Its Relationship to Pathologic Factor.
- Author:
Ho Jin JUN
;
Dong Kook PARK
;
Chan Young LEE
;
Jung Tak KIM
;
Do Sun LEE
;
Min JUNG
;
Jong Kwon PARK
;
Jin Woo RHU
;
Min Chol LEE
;
Na Hye MYEONG
- Publication Type:Original Article
- Keywords:
Colorectal carcinoma;
P53;
bcl-2
- MeSH:
Adenocarcinoma;
Antibodies, Monoclonal;
Clone Cells;
Colorectal Neoplasms*;
Humans;
Lymph Nodes;
Neoplasm Metastasis;
Oncogene Proteins;
Pathology
- From:Journal of the Korean Society of Coloproctology
1998;14(2):165-178
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was undertaken to evaluate the correlation between p53, bcl-2 expression and pathologic factors stage, anatomic location, histologic grade, gross pattern, lymph node metastasis of the colorectal cancer. METHODS: Analysis were made on archival pathology tissue of 56 patients with colorectal cancer. The oncoproteins were localized using commerically available monoclonal antibodies : DO-7 for, p53 and clone 124 for bcl-2. RESULTS: P53 protein was detected in 53 out of 56(94.6%) adenocarcinomas of the colorectal cancer and the most frequently expressed patterns of immunoreactivity of p53 were strong in intensity in 40 cases(71.4%) and were diffuse in pattern in 39 cases(69.6%). Bcl-2 protein was detected in 34 out of 56(60.7%) adenocarcinomas of the colorectal cancer and the most frequently expressed patterns of immunoreactivity of bcl-2 were weak in intensity in 17 cases(30.3%) and were diffuse in pattern in 16 cases(28.6%). There was no correlation between p53, bcl-2 expression and Dukes' stage, anatomic location ,histologic grade, gross pattern of tumor, lymph node metastasis of the colorectal cancer. CONCLUSION: 53 mutation and bcl-2 expression are frequent event in human colorectal carcinoma as shown in this study, but p53 and bcl-2 protein expression is not significant independent predicator of aggressiveness and progression of colorectal cancers.
