Experimental atudy on pulmonary embolism caused by lipiodol and absolute ethanol.
10.3348/jkrs.1992.28.6.888
- Author:
Jae Hyoung KIM
;
Byung Ihn CHOI
;
Seung Hyup KIM
;
In Ok AHN
;
Man Chung HAN
;
Chu Wan KIM
- Publication Type:Original Article
- MeSH:
Animals;
Embolization, Therapeutic;
Ethanol*;
Ethiodized Oil*;
Femoral Vein;
Hemorrhage;
Lung;
Pulmonary Embolism*;
Pulmonary Fibrosis;
Rats
- From:Journal of the Korean Radiological Society
1992;28(6):888-896
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pulmonary embolism of lipiodol or ethanol may occur inadvertently during the procedure of diagnostic or therapeutic embolization. We studied the nature of pulmonary damage, and its relation to the amount of lipiodol and ethanol embolized into the lung. Various doses of embolic agents(lipiodol 0.4cc/kg, 0.08cc/kg, absolute ethanol 0.4cc/kg, 0.03cc/kg and normal saline 0.4cc/kg)were injected intravenously through femoral vein in 50 rats(10 rats in each group). Pulmonary pathologic changes were analyzed on the 3rd and 28th days subsequent to injection. On the 3rd day, three of 10 lipiodol cases and all(10) ethanol cases showed multifocal pulmonary hemorrhages. Accompanying inflammatory cell infiltration was found only in lipiodol cases. On the 28th day, one of 10 lipiodol cases and four of 10 ethanol cases showed non-specific pneumopathy suggesting mild focal pulmonary fibrosis. The degree of pulmonary damage appeared to depend on the amount of injected embolic agents although their safety doses could not be clarified exactly. Therefore, we suggest careful injection of embolic agents, especially ethanol, during the embolization procedure to prevent possible pulmonary damage by inadvertent pulmonary embolism.
