Efficacy of Red Cell Distribution Width as Prognostic Factor for Sepsis-3 Patients in Emergency Department.
- Author:
Sung LEE
1
;
Dae Young HONG
;
Jong Won KIM
;
Sin Young KIM
;
Sang O PARK
;
Kyeong Ryong LEE
;
Kwang Je BAEK
;
Jin Yong KIM
Author Information
1. Department of Emergency Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea. palenova@naver.com
- Publication Type:Original Article
- Keywords:
Sepsis;
Red blood cell;
Prognosis;
Mortality;
Emergency departments
- MeSH:
C-Reactive Protein;
Comorbidity;
Emergencies*;
Emergency Service, Hospital*;
Erythrocyte Indices*;
Erythrocytes;
Hematologic Tests;
Humans;
Lactic Acid;
Male;
Mortality;
Prognosis;
Retrospective Studies;
Risk Factors;
ROC Curve;
Sensitivity and Specificity;
Sepsis;
Survivors
- From:Journal of the Korean Society of Emergency Medicine
2017;28(3):255-262
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Red cell distribution width (RDW) was introduced as a new biomarker for the prognosis of sepsis patients. In addition, the definition of sepsis has changed recently to sepsis-3 criteria. The aim of this study was to compare the efficacy of RDW as a prognostic factor for sepsis-3 patients in the emergency department. METHODS: We conducted a retrospective study of patients who were suspected of having sepsis between October, 2015 and April, 2016. The demographic data, comorbidities, blood test results, including RDW, lactate, C-reactive protein, and procalcitonin at admission, as well as the Mortality in Emergency Department Sepsis score were compared between the 30-day survivors and nonsurvivors. Analysis compared the areas under the receiver operator characteristic curves for 30-day mortality. Multivariate Cox proportional hazards regression analysis was performed to determine the risk factors for mortality. RESULTS: A total of 222 patients were included. The mean age was 75, 51.8% of the patient population was male, and the overall mortality rate was 16.7%. The non-survival group had higher RDW levels than the survivor group (14.5% vs 13.4%). The area under the receiver operating characteristic curve of RDW to predict mortality was 0.724. In a Cox proportional hazards analysis, RDW had 1.292 hazard ratio. Setting the RDW cutoff value to 14.3, we found that sensitivity and specificity of predicting mortality was 75.1% and 70.3%, respectively. CONCLUSION: It may be possible to use RDW to predict mortality in sepsis-3 patients.
