Identification of Anti-G in Pregnant Women with RhD Negative Blood: The First Case in Korea.
10.17945/kjbt.2017.28.3.304
- Author:
Sooin CHOI
1
;
Sun Joo YOON
;
Ji Young SEO
;
Sejong CHUN
;
Soo Young OH
;
Duck CHO
Author Information
1. Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. duck.cho@skku.edu
- Publication Type:Case Report
- Keywords:
RhD negative;
Hemolytic disease of fetus and newborn;
Rhogam;
Anti-G;
Absorption and elution
- MeSH:
Abortion, Spontaneous;
Adsorption;
Adult;
Agglutination;
Female;
Fetal Distress;
Follow-Up Studies;
Humans;
Korea*;
Phenotype;
Pregnancy;
Pregnant Women*;
Prenatal Care;
Rho(D) Immune Globulin
- From:Korean Journal of Blood Transfusion
2017;28(3):304-310
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anti-G positivity can be misinterpreted as the presence of anti-D or -C antigen in an antibody identification test, as this antibody is known to show agglutination to D or C antigen-positive red cells. Correct identification of anti-G is important in pregnant women, as prenatal care or the need for RhIG administration can vary between anti-D and -C versus anti-G cases. We recently encountered a D-negative case with suspected anti-D and -C, which was ruled out by adsorption and elution tests, and ultimately confirmed the presence of anti-G. The pregnant woman was a 33-year-old patient with cde Rh phenotype with a previous history of spontaneous abortion, followed by administration of RhIG. The spouse's Rh phenotype was CDe. Initial antibody identification test showed 2+ positivity to C (homozygotes and heterozygotes) and trace to 1+ positivity to D. Upon additional adsorption and elution with R0r (cDe/cde) and r'r (Cde/ cde) red cells, we identified the antibody present in the patient's serum as anti-G. The patient is currently under close follow-up monitoring for anti-G titer using antibody titer testing with both CDe and CcDEe red cells. Periodic fetal cerebral Doppler examination is being carried out without evidence of fetal distress.
