Quantitative Assessment of Lung Volumes using Multi-detector Row Computed Tomography (MDCT) in Patients with Chronic Obstructive Pulmonary Disease (COPD).
10.3348/jkrs.2008.59.2.91
- Author:
Sang Min LEE
1
;
Jin HUR
;
Tae Hoon KIM
;
Sang Jin KIM
;
Hyung Jung KIM
Author Information
1. Department of Radiology, Yonsei University College of Medicine, Seoul, Korea. khuhz@yuhs.ac
- Publication Type:Original Article
- Keywords:
Chronic obstructive pulmonary disease;
Computed tomography (CT);
Lung volume measurements;
Chest
- MeSH:
Humans;
Lung;
Lung Volume Measurements;
Pulmonary Disease, Chronic Obstructive;
Pulmonary Emphysema;
Respiratory Function Tests;
Thorax
- From:Journal of the Korean Radiological Society
2008;59(2):91-97
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate the clinical value of the multi-detector row computed tomography (MDCT) in the quantitative assessment of lung volumes and to assess the relationship between the MDCT results and disease severity as determined by a pulmonary function test (PFT) in Chronic Obstructive Pulmonary Disease (COPD) patients. MATERIALS AND METHODS: We performed a PFT and MDCT on 39 COPD patients. Using the GOLD classification, we divided the patients into three groups according to disease severity; stage I (mild, n=10), stage II (moderate, n=15), and stage III (severe, n=14). Using the pulmo-CT software program, we measured the proportion of lung volumes with attenuation values below -910 and -950 HU. RESULTS: The mean FEV1 (% of predicted) and FEV1/FVC was 82.2+/-2% and 66.2+/-3% in stage I, 53.5+/-11% and 52+/-6% in stage II, and 32.3+/-7% and 44.2+/-13% in stage III, respectively. Differences in lung volume percentages at each of the thresholds (-910 and -950 HU) among the 3 stages were statistically significant (p<0.01, p<0.01) and correlated well with the FEV1 and FEV1/FVC (r=-0.803, r=-0.766, r=-0.817, and r=-0.795, respectively). CONCLUSION: The volumetric measurement obtained by MDCT provides an accurate means of quantifying pulmonary emphysema.
