Pathological Analysis of 1,000 Cases of Transrectal Ultrasoundguided Systematic Prostate Biopsy: Establishment of New Sample Processing Method and Diagnostic Utility of Immunohistochemistry.
- Author:
Chang Lim HYUN
1
;
Hee Eun LEE
;
Haeryung KIM
;
Hye Seung LEE
;
So Yeon PARK
;
Jin Haeng CHUNG
;
Gheeyoung CHOE
Author Information
1. Department of Pathology, Seoul National University College of Medicine, Seoul, Korea. gychoe@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Prostate;
Prostatic neoplasms;
Needle biopsy;
Immunohistochemistry
- MeSH:
Adenocarcinoma;
Biopsy*;
Biopsy, Needle;
Diagnosis;
Immunohistochemistry*;
Paraffin;
Prostate*;
Prostatectomy;
Prostatic Intraepithelial Neoplasia;
Prostatic Neoplasms
- From:Korean Journal of Pathology
2006;40(6):406-419
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: We developed a new processing method for extended prostate needle biopsy, and evaluated diagnostic utility of routine immunohistochemistry in 1,000 consecutive unselected cases of transrectal ultrasound-guided systematic prostate biopsy. METHODS: Four to five biopsy cores were embedded in one paraffin block. All the biopsy cores were immunohistochemically stained with basal cell markers. RESULTS: The new sample processing method was technically perfect for making a diagnosis from extended prostate needle biopsy. Among 1,000 cases, there were 323 cases (32.3%) of adenocarcinoma, 5 cases of other malignant tumors, 9 cases of high-grade prostatic intraepithelial neoplasia without a carcinoma, and only 8 cases of atypical small acinar proliferation. Among the 323 cases of adenocarcinoma, there were 38 cases (11.8%) of microcarcinomas <0.1 cm and 101 cases (31.3%) of small adenocarcinomas <0.3 cm in length. In the needle biopsy specimens, 59 cases (18.3%) were classified as clinically insignificant carcinomas. Among them, 37 cases underwent radical prostatectomy, which turned out to be clinically significant carcinomas in 24 cases (64.9%). CONCLUSIONS: Routinely performed immunohistochemistry combined with the new sample processing method is very effective for detecting microscopic carcinoma foci as well as differentiating carcinoma from benign conditions mimicking cancer.
