The Morphologic Patterns of Diabetic Nephropathy in Koreans.
10.4132/KoreanJPathol.2009.43.1.36
- Author:
Si Hyong JANG
1
;
Moon Hyang PARK
Author Information
1. Department of Pathology, College of Medicine, Hanyang University, Seoul, Korea. parkmh@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Diabetes mellitus;
Diabetic nephropathy;
Kidney
- MeSH:
Atrophy;
Creatinine;
Diabetes Mellitus;
Diabetic Nephropathies;
Fibrosis;
Glomerulonephritis, IGA;
Humans;
Inflammation;
Kidney;
Kidney Failure, Chronic;
Sclerosis
- From:Korean Journal of Pathology
2009;43(1):36-42
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Diabetic nephropathy is the most common cause of end-stage renal disease and it has various pathologic features. We investigated the clinicopathologic differences between the histologic classes of diabetic nephropathy. METHODS: A total of 46 patients with diabetic nephropathy were evaluated. Morphologically, the renal lesions were divided into three categories: class 1, diffuse or nodular glomerulosclerosis: class 2, vascular change without evidence of glomerulosclerosis: and class 3, non-diabetic renal disease superimposed on diabetic glomerulosclerosis. We evaluated the laboratory findings and the histologic findings, including mesangial expansion, interstitial fibrosis and inflammation, arteriolar hyalinosis and tubular atrophy. RESULTS: The proportion of each class was 32 cases (70%), 4 cases (9%) and 10 cases (21%), respectively. The clinical and laboratory data showed no significant difference among the classes. For the groups of class 1, the group with nodular sclerosis showed a higher serum creatinine level than did the diffuse group (p=0.003). IgA nephropathy was the most common non-diabetic renal disease superimposed on diabetic glomerulosclerosis in our study. CONCLUSIONS: The patients with nodular glomerulosclerosis presented with a more progressed clinicopathological features than did the patients with class 1 diffuse glomerulosclerosis. We also found 21% of all the patients with diabetic nephropathy had superimposed non-diabetic renal disease in a Korean population.
