Increasing Recovery of Nontuberculous Mycobacteria from Respiratory Specimens over a 10-Year Period in a Tertiary Referral Hospital in South Korea.
10.4046/trd.2013.75.5.199
- Author:
Won Jung KOH
1
;
Boksoon CHANG
;
Byeong Ho JEONG
;
Kyeongman JEON
;
Su Young KIM
;
Nam Yong LEE
;
Chang Seok KI
;
O Jung KWON
Author Information
1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. wjkoh@skku.edu
- Publication Type:Original Article
- Keywords:
Nontuberculous Mycobacteria;
Mycobacterium tuberculosis;
Epidemiology;
Korea
- MeSH:
Epidemiology;
Humans;
Korea;
Lung Diseases;
Mycobacterium;
Mycobacterium avium Complex;
Mycobacterium tuberculosis;
Nontuberculous Mycobacteria*;
Republic of Korea*;
Retrospective Studies;
Tertiary Care Centers*;
Tuberculosis
- From:Tuberculosis and Respiratory Diseases
2013;75(5):199-204
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The number of patients with pulmonary disease caused by nontuberculous mycobacteria (NTM) has been increasing worldwide. The aim of this study was to evaluate long-term trends in the NTM recovery rate from respiratory specimens over a 10-year period in a tertiary referral hospital in South Korea. METHODS: We retrospectively reviewed the records of mycobacterial cultures of respiratory specimens at Samsung Medical Center from January 2001 to December 2011. RESULTS: During the study period, 32,841 respiratory specimens from 10,563 patients were found to be culture-positive for mycobacteria. These included 12,619 (38%) Mycobacterium tuberculosis and 20,222 (62%) NTM isolates. The proportion of NTM among all positive mycobacterial cultures increased from 43% (548/1,283) in 2001 to 70% (3,341/4,800) in 2011 (p<0.001, test for trend). The recovery rate of NTM isolates from acid-fast bacilli smear-positive specimens increased from 9% (38/417) in 2001 to 64% (1,284/1,997) in 2011 (p<0.001, test for trend). The proportion of positive liquid cultures was higher for NTM than for M. tuberculosis (p<0.001). The most frequently isolated NTM were Mycobacterium avium-intracellulare complex (53%) and Mycobacterium abscessus-massiliense complex (25%). CONCLUSION: The recovery rate of NTM from respiratory specimens in South Korea has increased steadily.
